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Feb 5, 2020
Published
Apr 30, 2020
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vol 6 no 1
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Abstract

Asthma is an inflammatory disease or chronic airway inflammation. Nigella sativa extract and oil are proven to be used to improve airway inflammation. This study consisted of 7 groups. The normal group (K1), negative group (K2), theophylline (K1), Nigella sativa extract (K4), Nigella sativa oil (K5). 0.9% intraperitoneally, and on the 14th day, the mice were re-sensitized intraperitoneally with a 20µg OVA + 2 mg of Alhydrogel in 1 mL of sterile NaCl 0.9%. On the 21st, 23rd, 25th day, the OVA1% was inhaled. On the 26th to 39th day, the K3 mice were given theophylline 0.338 mg/day, K4 mice were given Nigella sativa extract at a dose of 1 mL/day and K5 mice were given Nigella sativa oil at a dose of 0.1mL / day. On the 40th day, the mice were terminated for analysis of the thickness of the bronchial epithelium. Comparison between groups of Nigella sativa extract on average 15.5 ± 2.22 µm and Nigella sativa oil average of 14.05 ± 3.87 µm p-value = 0.488 means that between the Nigella sativa extract group and Nigella sativa oil there was no difference meaningful. statistically as an antiasthma in decreasing the size of the thickness of the bronchial epithelium

Keywords

Asthma bronchial epithelial thickness Nigella sativa extracts Nigella sativa oil

Article Details

References

  1. Akhtar, M., Maikiyo, A. M., Khanam, R., Mujeeb, M., Aqil, M., & Najmi, A. K. (2012). Ameliorating effects of two extracts of Nigella sativa in middle cerebral artery occluded rat.
  2. Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A. K., Siddique, N. Ali, Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337–352. https://doi.org/10.1016/S2221-1691(13)60075-1
  3. Balaha, M. F., Tanaka, H., Yamashita, H., Abdel Rahman, M. N., & Inagaki, N. (2012). Oral Nigella sativa oil ameliorates ovalbumin-induced bronchial asthma in mice. International Immunopharmacology, 14(2), 224–231.
  4. Badan Penelitian dan Pengembangan Kesehatan. (2013). Riset Kesehatan Dasar (Riskesdas) 2013. Laporan Nasional 2013, 1–384. https://doi.org/1 Desember 2013
  5. Baratawidjaja, K. G., & Rengganis, I. (2010). Imunologi Dasar (8th ed.). Jakarta Indonesia: Balai Penerbit Fakultas Kedokteran Universitas Indonesia, 2010.
  6. Dara, A. I., & Husni, P. (2017). Teknik Meningkatkan Kelarutan Obat. Farmaka Volume 15 Nomor 4, 4(Desember 2017), 1–15.
  7. F V Manvi, B. K. N. A. S. S. (2011). Pharmacological Screening of Combined Extract of Annona Squamosa and Nigella Sativa F V Manvi , B K Nanjawade and Sanjiv Shing. International Journal of Pharma and Bio Sciences Research, 2, 520–529.
  8. Fehrenbach, H., Wagner, C., & Wegmann, M. (2017). Airway remodeling in asthma: what really matters. https://doi.org/10.1007/s00441-016-2566-8
  9. Global Initiative For Asthma (GINA). (2017). Global Strategy For Asthma Management and Prevention. Global Initiative for Asthma, http://ginasthma.org/2017-gina-report-global-strat. https://doi.org/10.1183/09031936.00138707
  10. Gharby, S., Harhar, H., Guillaume, D., Roudani, A., Boulbaroud, S., Ibrahimi, M., Charrouf, Z. (2015). Chemical investigation of Nigella sativa L. seed oil produced in Morocco. Journal of the Saudi Society of Agricultural Sciences, 14(2), 172–177.
  11. Halwani, R., Al-Muhsen, S., & Hamid, Q. (2010). Airway remodeling in asthma. Current Opinion in Pharmacology, 10(3), 236–245.
  12. Koshak, A., Li, W., Emad, K., Siraj, W., & Alamoudi Omer, Demerdash Abdulrahman, Qutub Majdy, Pushparaj Peter Natesan, H. M. (2017). Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial. Phytotherapy Research, 31(3), 403–409.
  13. Paarakh, P. M. (2010). Nigella sativa Linn.- A comprehensive review. Indian Journal of Natural Products and Resources, 1(4), 409–429.
  14. Palupi, D. A., & Hasanah, F. N. (2018). Pengaruh Pemberian Suplementasi Minyak Zaitun Terhadap Penurunan Ketebalan Epitel Bronkus Pada Menct Asma Yang Diinduksi Ovalbumin. Cendekia Journal of Pharmacy, 2(2), 109–115.
  15. PDPI. (2003). Asma. Pedoman Diagnosis Dan Penatalaksaan Asma Di Indonesia, 105.
  16. Rogliani, P., Ora, J., Puxeddu, E., & Cazzola, M. (2016). Airflow obstruction: is it asthma or is it COPD? International Journal of Chronic Obstructive Pulmonary Disease, 11, 3007–3013.
  17. Sriwahyuni, E., Risza, Q., & Yuni, A. . (2010). Black Seed (Nigella sativa) Extract Prevent The Thickening of Bronchus and Increase The Circumference Of Bronchial Lumen in Asthma Model Mice. Jurnal Kedokteran Brawijaya, 26(1), 37–42.